Description of the drug Clonidine
Clonidine is a medication of central action, designed to treat high blood pressure (hypertension) and migraine. By stimulating alpha-receptors in the brain Clonidine reduces vascular resistance.
The drug Clonidine is also used for treatment of acute myocardial infarction (if there are no signs of cardiogenic shock), headache of vascular origin, pheochromocytoma, dysmenorrhea and menopause (treatment of vasomotor symptoms), syndrome of Gilles de la Tourette and nicotine dependence.
Action of the drug Clonidine is accompanied by the expansion of peripheral blood vessels all over the organism. The drug increases renal blood flow, at the same time improving the tone of cerebral blood vessels and reducing cerebral blood flow, and has a strong sedative and analgesic effect.
At intake Clonidine orally, it is well absorbed. The half-life of Clonidine is about 12-16 hours, the duration of therapeutic action from 2 to 24 hours. At taking the drug Clonidine orally, about 60% of the drug is excreted by the kidneys, mainly as metabolites.
Hypotensive impact of Clonidine is accompanied by a decrease in cardiac output that reduces peripheral vascular resistance, including blood vessels of the kidneys. The drug Clonidine also reduces the intraocular pressure by decreasing secretion and improving the outflow of aqueous humor.
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